Fruitland is located on U.S. Route 13, a major north-south highway which intersects with U.S. Route 50, a major east-west highway.

Fruitland businesses are served by Salisbury-Ocean City Regional Airport, the second largest airport in Maryland. They ship and receive products in the state's second largest port. Both are minutes away.

Major rail carriers (Norfolk SouthernCSX) operate in Fruitland.

Shore Transit is the local bus transportation company.

 Greyhound is the only national bus transportation company located in Wicomico County.